08- Investigating the Copper Mediated Dityrosine Cross-Linking of Alzheimer’s Disease Amyloid-β Plaques

Primary Author

Elisa Carian

Additional Author(s)

Madeline Colley, Andrea Kelley, Grace Samenuk, Krista Berlin, Stephan Bach, George Perry

Faculty Mentor

Stephen Bach

Additional Mentor(s)

George Perry

Abstract

Alzheimer’s Disease (AD) is a a progressive, age related neurodegenerative disease characterized by the accumulation of senile plaques and neurofibrillary tau tangles. These plaques are made up of amyloid-beta peptides and may aggregate by copper mediated dityrosine cross-linking of the amyloid- β. The method used to analyze the amyloid-beta plaques and determine the proteins and peptides within the plaques is matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The purpose of this experiment is to investigate the copper mediated-dityrosine cross-linking of amyloid-beta(1-42) to determine if oxidative stress alone is enough to induce fibrillation.

Presentation

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