Acquired Epilepsy and Adult Neurogenesis


Primary Author

Marissa Coppin

Faculty Mentor

Jenny Hsieh

Additional Mentor(s)

Dr. Gopakumar Changarathil


According to the Centers of Disease Control and Prevention, 3.4 million Americans suffer from epilepsy disorders. Approximately 50% of these individuals with epilepsy have acquired seizures from other damaging events that lead to traumatic brain injuries, while others suffer from genetic forms. Patients that suffer from chronic epilepsy experience recurrent seizures with a higher risk of death along with psychosocial disorders and an economic burden of about 9.4 billion nationwide. Researchers have investigated how seizure activity affects neuronal morphologies in the hippocampus in mouse models, proving that some neurons migrate ectopically to the hilus with chronic seizure activity during adult neurogenesis. The Hsieh lab studies the gaps in these mechanisms to hopefully find a way to prevent this ectopic migration and abnormal neuronal morphology that causes seizures and potentially death.


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